MULTIPLE SCLEROSIS/TNF THERMOSTAT
Okay I post this article only to introduce the second cytokine to you after speaking on IL-1 yesterday. This is TNF . It stands for Tumor Necrosis Factor. In this article a hypothesis is put forth that explains a case of a blocker to the receptor of TNF and the negative consequences of exacerbation of Multiple sclerosis. How can that be?
Since the main motivation of studying these molecules out of my fiield of expertise and inventing a software to assimilate the knowledge was the death of 2 of my friends and classmates. Ed Temple and Cassandra Williams. The treatments available today were not available during the time that they were living due to the infancy of the research regarding them (cytokines). Our current thinking is that the overkill of TNF action may cause the lining of the fast acting nerves (myelin) to be eaten up /destroyed/loose its integrity.
This article deals with the thermostat-like control of the production of TNF. Like a heater when its too cold causing the heat to come on. the TNF production goes up when its effects are not "sensed". A product of TNF action when reduced can signal a greater degree of production. All of this is a part of NEGATIVE FEEDBACK INHIBITION, a well known factor involved in BIOCHEMISTRY.
This may explain the worsening of multiple sclerosis involves TNF overproduction and over action.
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